After reading theology at Balliol College, Oxford, Claire developed expertise in medical ethics as a Research Fellow at King's College, London. She published The Manual for Research Ethics Committees (KCL, 1995, republished each year) and later The Ethics of Medical Research on Humans (CUP 2001) and became a national expert in research ethics committees, developing and teaching an intellectual framework for the ethical scrutiny of medical research and working with the Department of Health to create a comprehensive network of ethics committees across the UK. Claire then moved to work for the Archbishops' Council of the Church of England as policy adviser in medical ethics and also environmental issues.
She led the efforts to shift the Church's thinking on environmental issues, offering a sound theological basis and practical guidance to change minds and hearts across the country. She published Sharing God's Planet (CHP 2005); How many lightbulbs does it take to change a Christian (CHP 2007), and; Don't stop at the lights (CHP 2008). During that time Claire became a lay Canon at St Paul's Cathedral and in 2003 co-founded St Paul's Institute, where she co-edited a book of Rowan Williams' dialogues on global issues The Worlds We Live In (DLT 2005). In 2008 she left the Archbishops' Council to found a charity, The Ethics Academy, and published Hero's Journal (The Ethics Academy, 2009), a programme teaching moral strength and courage to young people and adults through the story of the 'hero's journey'. The programme was offered in schools of every kind, to NEETs, street homeless people, asylum seekers and victims of torture. Claire combined the charity work with being Development Director at St Martin-in-the-Fields until she came to Westminster Abbey as founder director of its Institute in 2012.
Claire has been a member or chair of numerous public and advisory bodies, including the Royal Society's Science in Society Committee, the 10 Downing St coalition on climate change, the Sustainable Development Education Panel of the Department for Education and DEFRA, Central Oxford Research Ethics Committee, the Banking Code Standards Board and the Royal College of Paediatrics Ethics Committee. She is currently member of the British Medical Association's Medical Ethics Committee, Unilever's Central Research Ethics Advisory Committee and the McDonald Centre for public theology and ethics, Christ Church, Oxford.